Fresh analysis reveals that people who discontinue popular slimming jabs like Wegovy and Mounjaro may regain lost weight at a significantly accelerated pace than those who end traditional lifestyle plans.
Published data in a prominent medical journal shows that while overweight people frequently drop about a fifth of their body weight while undergoing treatment, the mass returns at an average rate of 0.8 kg per month after stopping.
"Individuals using these medications should be cognizant of the risk of rapid weight regain when the medication is stopped," warns lead investigator Dr. Susan Jebb.
That rate of regain means a return to starting mass in about one and a half years.
Analyzing Treatments
The study, which examined dozens of studies involving over 9,000 of participants, contrasted the results of the injectable medications with other pills.
Researchers note that people who lose weight through dieting usually see a less rapid weight regain—perhaps 0.1 kg a month—after stopping.
Explaining the Fast Rebound
Nutrition scientists suggest the mode of action of the drugs accounts for the amplified regain.
These medications copy a natural hormone called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Sustained high doses of GLP-1 levels several times higher than the body's typical production could lead to the system to produce less of its endogenous hormone, and may also lessen sensitivity to its effects," said Dr. Adam Collins, a dietetics researcher.
"Discontinuation of this medication leads to hunger is unsuppressed, making excessive eating a significant risk."
An Ongoing Issue?
Health authorities suggest the jabs for people with obesity-related health risks, accompanied by prescribed lifestyle changes.
Professionals contend that, given the significant potential of weight regain, the therapy might need to be ongoing.
This view is supported by pharmaceutical companies, who state that the findings "emphasize the chronic character of excess weight," comparing it to managing diseases like hypertension.
User Accounts
Individuals who have discontinued the medication report a powerful resurgence of hunger.
"I experienced a switch flipping and you're instantly extremely hungry," described one woman.
This challenge is compounded if individuals have not established sustainable lifestyle or habit changes during therapy.
Significant Interest
Figures indicate that millions of adults in the UK have tried these injections in the last 12 months, with interest continuing to grow.
- Adoption is more common among women compared to men.
- The middle-aged age group shows the greatest usage rates.
- Many access the drugs through private prescriptions rather than the NHS.
In conclusion, clinicians caution that while the jabs are potent agents for shedding pounds, they are not a standalone cure and lasting health benefits likely depends on combined behavioural changes.
